报告人：Prof Li Jiaxu

报告题目：Translate dynamic models into an algorithm for an artificial pancreas

摘要：Multi-millions of people suffer diabetes mellitus, including type 1 diabetes and type 2 diabetes, that is caused by the lack of or relatively insufficient, insulin produced from pancreatic beta-cells. Exogenous insulin or its analogues must be administered in daily base to utilize and lower the chronic high glucose level through an artificial pancreas to achieve ideal clinical treatment. Artificial pancreas is a medical device consisting of an insulin pump, a continuous glucose monitoring systems(CGMS), and a set of closed loop control(CLC) algorithm. Even such systems are commercially available in market, an effective CLC algorithm is still lacking in handling the delayed effects of insulin in delivery mechanisms, glucose monitoring system, and the hepatic glucose production(HGP). The time discrepancies and dose inaccuracies often cause undesired glucose fluctuations including both hyperglycemia and dangerous hypoglycemia.

In this talk, we first report an integrated system, consisting of several sub dynamic models, through which a CLC algorithm for artificial pancreas with single pump. The effectiveness of the algorithm is validated with clinical data. Secondly, we introduce a novel model taking the other important pancreatic hormone, glucagon, into account. We shall discuss the development of CLC algorithm based on this model for an artificial pancreas with dual pump that can respectively deliver both insulin and glucagon according to the needs of patient.

报告时间：2022年11月19日上午10：00-13：00

报告形式：腾讯会议，会议号：   605-458-454

获取会议密码请发邮件至：1599119729@qq.com

报告人简介：www.math.louisville.edu/~jli/